Spectrophotometric methods for determination of zolpidem tartrate in tablet formulation
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چکیده
منابع مشابه
Validated Spectrophotometric method for the estimation of Zolpidem tartrate in Bulk and Tablet Formulation
Three simple, precise and economical UV spectrophotometric methods have been developed for the estimation of Zolpidem tartrate in bulk and tablet formulations. Zolpidem tartrate has absorbance maxima at 293 nm in zero order spectrum method (Method A ) First order derivative spectra of drug, showed λ maxima = 305 nm and λ minima = 280 nm and amplitude difference was measured for the respective c...
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Conventional solid dosage form suffers from problem like difficulty in swallowing with age, onset of action and physiological factor of patient like gastric emptying time. To overcome this mouth dissolving tablet is a newer approach to drug delivery. Zolpidem is preferentially used for the short term treatment of insomnia. The aim of present study is to formulate and evaluate mouth dissolving t...
متن کاملFormulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique
The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...
متن کاملValidated RP-HPLC Method for the Determination of Zolpidem tartrate in Bulk and Tablet Dosage Form
A novel, simple and economic reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of zolpidem tartrate in bulk and tablet dosage form with greater precision and accuracy. Separation was achieved on C18 column (250X4.6mm i.d.,5μm) in isocratic mode using methanol and acetonitrile in the ratio 50:50 (v/v) as mobile phase, pumped in to the col...
متن کاملFormulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 3(2) full factorial design. The ratio of HPMC K4M and PVP K30 (X(1)) and the concentration of melt binder (X(2)) were selected as independent variables, and drug release at 1 hr (Q(1)), 4 hr (Q(4)), 8 hr...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Bioallied Sciences
سال: 2010
ISSN: 0975-7406
DOI: 10.4103/0975-7406.72142